Tissue Lysates
Cayman Chemical ProstaglndIn E3 100ug
PGE3 is formed via the COX metabolism of EPA.{1145} In human ocular tissue, it comprises 2.4% of the COX products formed.{1145} When applied to the eyes of a rabbit, a 1 UG dose of PGE3 decreases IOP from 21 mmHg to about 17 mmHg.{1225}
Cayman Chemical ProstaglndIn F3a 100ug
PGF3α is a COX product of EPA. The biosynthesis of PGF3α from EPA was demonstrated in vitro in human and rabbit ocular tissues.{1145} It has only 25% affinity at the ovine luteal FP receptor compared to PGF2α.{2058}
Cayman Chemical 20-carboxy LeukotrIen B4 100ug
20-carboxy LTB4 is a metabolite of LTB4 in human neutrophils. In human leukocytes, LTB4 is inactivated by the enzyme LTB4 20-hydroxylase. The resulting 20-hydroxy LTB4 is further oxidized to 20-carboxy LTB4.{377} LTB4 metabolism in isolated rat hepatocytes also results in production of 20-carboxy LTB4 along with other ω-oxidation products.{1032} The biological activity of 20-carboxy LTB4 is only about 2.6% compared to that of LTB4 in causing PMNL degranulation.{399}
Cayman Chemical 11-trns LeukotrIen C4 100ug
11-trans LTC4 is a C-11 double bond isomer of LTC4. LTC4 undergoes slow temperature-dependent isomerization to 11-trans LTC4 during storage. 11-trans LTC4 is produced in smaller amounts relative to LTC4 in ionophore-stimulated HMC-1 cells (a human mast cell line) and equine eosinophils{11135}, but not in human neutrophils or RBL-1 cells.{11184} It is nearly equipotent with LTC4 for contraction of guinea pig parenchymal and ileum.{2070,11187} In a radioligand binding assay using guinea pig ileum as a cysteinyl leukotriene receptor preparation, the pKis for LTC4 and 11-trans LTC4 were determined to be 6.42 and 6.58, respectively.{11187}
Cayman Chemical LeukotrIen B4 EthnolamID 100ug
A theoretical 5-LO metabolite of AEA; acts as a potent antagonist of the human BLT1 receptor (Ki = 1.22 nM)
Cayman Chemical FumonIsIn B3 1mg
A mycotoxin; cytotoxic to primary rat hepatocytes at 125, 250, and 500 µM; induces hepatocyte nodules in rats at 0.05% in the diet for 14 or 21 days; has been detected in corn and corn-based foods and livestock feeds
Perkin Elmer US LLC Universal Gas Cell Holder - 10 cm
This holder ships with various Starter Packs, such as the Gas Sampling Starter Pack (L1272267).
Cayman Chemical SynthetIc AlysIn 1mg
An isothiocyanate with diverse biological activities; active against a variety of bacteria; directly inhibits PAH-induced CYP1A1 and CYP1A2 activity in MCF-7 cells at 0.5-2.5 µM; inhibits proliferation of HCT116 colon cancer cells (IC50 = 50s = 168 and 20 µM, respectively)
Cayman Chemical LeukotrIen F4 100ug
LTF4 is a cysteinyl-leukotriene produced in vitro, but not reported to date in vivo. It is formed by the incubation of LTE4 with γ-glutamyl transpeptidase and glutathione. LTF4 is a weak agonist in its ability to contract vascular smooth muscle.{547} The rank order of potency of the cysteinyl-leukotrienes to contract vascular smooth muscle is LTD4 > LTC4 > LTE4 >> LTF4.{547,548}
American Research Products Inc MITOCHONDRIAL COMPLEX IV CYTOC
5000265775 MITOCHONDRIAL COMPLEX IV CYTOC
Cayman Chemical SynthetIc PF-1022A 1mg
A cyclodepsipeptide with anthelmintic activity; oral administration induces worm excretion in a chicken model of A. galli infection from 0.5-2 mg/kg; induces parasite clearance in jird models of H. contortus, O. ostertagi, or T. colubriformis infection (ED95s = 0.11, 0.33, and 0.11 mg/animal)
Cayman Chemical 17 S-HDHA-d5 100ug
An internal standard for the quantification of 17(S)-HDHA by GC- or LC-MS
Cayman Chemical GnglIosIde GQ1bporcIna 100ug
A sphingolipid molecular species isolated from porcine brain with primarily C18:0 fatty acyl chain lengths; stimulates phosphorylation of several ecto-type protein kinase substrates on the surface of GOTO human neuroblastoma cells at 5 nM; promotes differentiation of mESCs to neuronal precursor and glial cells via activation of the ERK1/2 pathway; induces differentiation of murine keratinocytes through phosphoinositide turnover